2013 · FINDING
CITEDCIRS Treatment
Improved symptoms in chronic inflammatory response syndrome patients
⚠ RESEARCH USE ONLY · NOT FDA-APPROVED FOR HUMAN USE · NOT MEDICAL ADVICE
COGNITIVERESEARCH
VIP.
The Neuroprotective Gut-Brain Peptide
AKA · Vasoactive Intestinal Peptide · Vasoactive Intestinal Polypeptide
COGNITIVEHEALINGIMMUNENASAL SPRAYSNASALSUBCUTANEOUS
Multi-system peptide with powerful anti-inflammatory and neuroprotective effects. Researched for CIRS (mold illness), gut disorders, and neurodegeneration.
~2 minutes (rapid degradation)
Half-life
4
Citations
3
Routes
4
Categories
Store
Storage
45
Popularity
AT A GLANCE.
§ 01 · TL;DRTHE QUICK READ.
Multi-system peptide with powerful anti-inflammatory and neuroprotective effects. Researched for CIRS (mold illness), gut disorders, and neurodegeneration.
Reduces inflammation throughout the body, protects neurons, and regulates gut and immune function.
Often used as part of CIRS protocol. Start low and titrate up.
WHAT IT MIGHT HELP WITH.
1
Powerful anti-inflammatory effects
2
Neuroprotection
3
Gut barrier support
4
Immune system regulation
5
May help CIRS/mold illness
6
Circadian rhythm support
HOW IT WORKS.
§ 02 · MECHANISMReduces inflammation throughout the body, protects neurons, and regulates gut and immune function.
28-amino acid peptide acting on VPAC1/VPAC2 receptors. Modulates cAMP signaling, reduces inflammatory cytokines, and provides neuroprotection via multiple pathways.
WHO IT'S FOR
- ✓CIRS/mold illness patients
- ✓Chronic inflammatory conditions
- ✓Gut health issues
- ✓Neuroinflammation
- ✓Autoimmune support
WHO SHOULD AVOID
- ✕Low blood pressure
- ✕Those on blood pressure medications
- ✕Pregnant/nursing
- ✕Diarrhea-prone individuals
THE RESEARCH.
§ 03 · 4 STUDIES2006 · FINDING
CITEDNeuroprotection
Protected neurons from various toxic insults in animal models
2010 · FINDING
CITEDIBD Research
Reduced intestinal inflammation in colitis models
2024 · FINDING
CITEDLong COVID Pilot Study
Preliminary data suggests potential benefit for post-acute sequelae of COVID-19 (Long COVID)
DOSING PROTOCOL.
§ 04 · DOSINGTYPICAL RANGE
Often used as part of CIRS protocol. Start low and titrate up.
50-200mcg intranasally, 1-4x daily
FREQUENCY
Most-cited schedule
1-4 times daily depending on condition
ROUTES
Delivery methods
NASAL · SUBCUTANEOUS · INTRAVENOUS
HALF-LIFE
Steady state drives frequency
~2 minutes (rapid degradation)
STORAGE
Protect from light, refrigerate
Store lyophilized at
⚠ NOTE
These are reported protocols from research literature and practitioner accounts, not prescriptions. No FDA-approved human dose exists for research compounds. Anyone using VIP should work with a qualified physician and source from a supplier providing third-party COAs.
FORMS AVAILABLE
- · Nasal spray (most common)
- · Subcutaneous injection
- · IV (clinical)
⚠ RESEARCH INFORMATION ONLY · NOT MEDICAL ADVICE
COMMON STACKS.
§ 05 · COMBINATIONSSIDE EFFECTS & RISKS.
§ 06 · SAFETY·
Diarrhea
Occasional · mild
VIP relaxes smooth muscle
·
Flushing
Occasional · mild
•
Low blood pressure
Rare · moderate
VIP is a vasodilator
·
Nasal congestion
Common (nasal) · mild
WHERE TO SOURCE
§ 07 · SUPPLIERPEAK LAB
PEPTIDES
PEPTIDES
SUPPLIER OF RECORD · 12 BATCHES PASSED
We tried nine suppliers across 2025 and kept picking PEAK LAB for VIP: 99.4% HPLC purity, COA on every batch, cold chain intact. Shop through our link and we earn a small commission — affiliate relationship is disclosed.
COMMON QUESTIONS.
§ 08 · FAQWhat is CIRS?
Chronic Inflammatory Response Syndrome, often triggered by mold exposure. VIP is part of the Shoemaker protocol for treatment.
Why nasal administration?
VIP is rapidly degraded in blood. Nasal delivery allows direct brain access and avoids first-pass metabolism.
Can VIP help gut issues?
Research suggests it may help inflammatory bowel conditions by reducing gut inflammation and supporting the intestinal barrier.
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