2023 · FINDING
CITEDBillon et al. — mouse endurance
Sedentary mice given SLU-PP-332 ran ~50% farther and showed muscle fiber-type shifts mimicking endurance training.
⚠ RESEARCH USE ONLY · NOT FDA-APPROVED FOR HUMAN USE · NOT MEDICAL ADVICE
WEIGHT LOSSRESEARCH
SLU-PP-332.
The exercise-in-a-vial compound — preclinical gold, zero human data
AKA · Exercise Mimetic · ERR Agonist
WEIGHT LOSSLONGEVITYTRENDINGORAL
Not a peptide technically — a small molecule that activates estrogen-related receptors (ERRα, β, γ), the same transcription factors exercise activates. In mice: endurance up, fat down, no treadmill required. Humans: tba.
Under investigation
Half-life
2
Citations
1
Routes
3
Categories
67
Popularity
AT A GLANCE.
§ 01 · TL;DRTHE QUICK READ.
Not a peptide technically — a small molecule that activates estrogen-related receptors (ERRα, β, γ), the same transcription factors exercise activates. In mice: endurance up, fat down, no treadmill required. Humans: tba.
Tricks your muscles into thinking they just did a workout. Activates the same gene-expression program exercise does — mitochondrial biogenesis, fat oxidation, endurance adaptation.
Extreme research-only status. Not a traditional peptide.
WHAT IT MIGHT HELP WITH.
1
~50% increase in running endurance in sedentary mice
2
10–12% body fat reduction without caloric restriction
3
Improved insulin sensitivity
4
Does NOT cause cardiac hypertrophy (unlike older ERR compounds)
5
Extremely new — being positioned as an exercise mimetic drug
HOW IT WORKS.
§ 02 · MECHANISMTricks your muscles into thinking they just did a workout. Activates the same gene-expression program exercise does — mitochondrial biogenesis, fat oxidation, endurance adaptation.
Pan-ERR agonist (α, β, γ). Drives PGC-1α-mediated transcriptional reprogramming of skeletal muscle: upregulated mitochondrial biogenesis, fatty acid oxidation, oxidative phosphorylation, slow-twitch fiber conversion.
WHO IT'S FOR
- ✓Researchers studying ERR signaling
- ✓Exercise mimetic drug development
WHO SHOULD AVOID
- ✕Everyone outside research context
- ✕Pregnancy
- ✕Anyone expecting proven human efficacy
THE RESEARCH.
§ 03 · 2 STUDIES2023 · FINDING
Xu et al. — obesity model
Obese mice lost 10–12% body fat on high-fat diet with SLU-PP-332; no reduced food intake.
DOSING PROTOCOL.
§ 04 · DOSINGTYPICAL RANGE
Extreme research-only status. Not a traditional peptide.
No established human dose. Animal studies: 5–10mg/kg oral.
FREQUENCY
Most-cited schedule
Unknown for humans
ROUTES
Delivery methods
ORAL
HALF-LIFE
Steady state drives frequency
Under investigation
⚠ NOTE
These are reported protocols from research literature and practitioner accounts, not prescriptions. No FDA-approved human dose exists for research compounds. Anyone using SLU-PP-332 should work with a qualified physician and source from a supplier providing third-party COAs.
FORMS AVAILABLE
- · Research-only; oral small molecule
⚠ RESEARCH INFORMATION ONLY · NOT MEDICAL ADVICE
SIDE EFFECTS & RISKS.
§ 06 · SAFETY!
Unknown human side effect profile
Unknown · serious
Zero human data — any claims are extrapolation
!
Theoretical reproductive effects
Theoretical · serious
ERRs involved in reproductive tissues
WHERE TO SOURCE
§ 07 · SUPPLIERPEAK LAB
PEPTIDES
PEPTIDES
SUPPLIER OF RECORD · 12 BATCHES PASSED
We tried nine suppliers across 2025 and kept picking PEAK LAB for SLU-PP-332: 99.4% HPLC purity, COA on every batch, cold chain intact. Shop through our link and we earn a small commission — affiliate relationship is disclosed.
MORE ON SLU-PP-332.
§ 10 · FIELD NOTES◆ Research Updates
SLU-PP-332: The Exercise Mimetic That Works In Mice
A small molecule that makes sedentary mice run 50% farther. No human data yet. But the mechanism is real — and different from everything else.
7 min·READ →
◆ Deep Dives
MOTS-c: The Mitochondrial Peptide That's Finally Getting Traction
Encoded in mitochondrial DNA, it's a metabolic regulator that mimics exercise adaptations. Human trials are starting. Here's what we actually know.
7 min·READ →
◆ Deep Dives
KPV: The Anti-Inflammatory Tripeptide Nobody Talks About
A three-amino-acid fragment of α-MSH with potent anti-inflammatory effects, oral bioavailability, and a remarkably clean safety record. Why is nobody talking about this?
6 min·READ →
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