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CJC-1295

Also known as: Mod GRF 1-29, CJC-1295 DAC, CJC-1295 no DAC

The GHRH Amplifier

A GHRH analog that amplifies growth hormone release. Often stacked with Ipamorelin for synergistic effects.

Research🔥 Trending 💪 Muscle & Recovery👃 Also available as nasal spray

How It Works

Simple Explanation

Extends the duration of natural GH release by mimicking growth hormone releasing hormone (GHRH).

Technical Details

Modified GHRH analog with increased half-life. DAC version provides sustained release; no-DAC version allows pulsatile dosing.

Pharmacokinetics & Storage

Half-Life

~30 minutes (no DAC) / ~8 days (with DAC)

Duration in circulation

Storage Requirements

Before use: Store lyophilized powder at -4°F to 39°F (-20°C to 4°C)

After reconstitution: No DAC: Use within 2-3 weeks refrigerated. DAC version more stable, 4+ weeks refrigerated

Reconstitute with bacteriostatic water. DAC version is more stable but requires different dosing protocol.

Research Timeline: What Studies Have Observed

Based on clinical trial data and published research. Individual responses may vary significantly.

Week 1

Research shows initial GH elevation begins. When stacked with GHRP, synergistic effects observed from first dose.

Weeks 2-4

Studies document improved sleep quality and recovery. GH-mediated benefits begin accumulating.

Weeks 5-8

Clinical research indicates body composition changes becoming noticeable. Enhanced recovery from training well-established.

Weeks 12+

Research suggests continued improvements in lean mass, fat loss, and anti-aging markers. Optimal results with 3-6 month protocols.

Benefits

Amplified GH release when stacked
Improved body composition
Enhanced recovery
Better sleep quality
Synergy with secretagogues

Potential Side Effects

Flushing

Common initially

mild

Water retention

Occasional

mild

Fatigue

Rare

mild

Known Interactions

Based on clinical research and pharmacological studies. Always consult a healthcare provider about potential interactions.

Ipamorelin/GHRPs

monitor

Intentionally combined in research for synergistic GH release. CJC-1295 amplifies the pulse triggered by GHRPs.

Insulin

caution

Both affect glucose metabolism. Research protocols time doses carefully, typically using peptides when fasted.

Somatostatin/Octreotide

avoid

Somatostatin inhibits GH release. These would antagonize CJC-1295 effects.

Research Highlights

Extended GH Elevation (2006)

Sustained GH elevation for several days (DAC version)

View Study

CJC-1295/Ipamorelin Combination (2023)

Synergistic GH release confirmed when combined with ipamorelin in clinical settings

View Study

Frequently Asked Questions

What's the difference between CJC-1295 with and without DAC?

DAC (Drug Affinity Complex) extends half-life from 30 minutes to ~8 days. No DAC allows natural pulsatile GH release; DAC provides more constant elevation. Most research prefers no DAC for physiologic patterns.

Why combine CJC-1295 with ipamorelin?

They work through different mechanisms - CJC-1295 (GHRH pathway) amplifies release, ipamorelin (ghrelin pathway) triggers the pulse. Together they produce significantly greater GH release than either alone.

Is Mod GRF 1-29 the same as CJC-1295 no DAC?

Yes, they're the same compound. Mod GRF 1-29 is the technical name for the modified GHRH fragment. 'CJC-1295 no DAC' or 'CJC-1295 without DAC' are common trade names.

What's the flushing side effect?

Some experience facial flushing/warmth shortly after injection. This is common with GHRH analogs and typically diminishes over time. It indicates the peptide is active.

Who Is It For

GH optimization seekers
Stack with Ipamorelin
Athletes
Anti-aging protocols

Who Should Avoid

Cancer history
Active malignancy
Pregnant/nursing

How It Compares

Research-based comparisons with similar peptides. Individual responses and circumstances should guide decisions.

💪vs SermorelinResearch

Sermorelin is the original GHRH analog with extensive clinical use. CJC-1295 has improved stability and potency. Both work through GHRH pathway.

💪vs IpamorelinResearch

Different pathway - ipamorelin triggers GH via ghrelin receptors. Often combined rather than used as alternatives.

Research Dosing Protocols

Common Research Protocol

No DAC: 100mcg 2-3x daily. DAC: 2mg weekly

Administration Frequency (per studies)

No DAC: 2-3x daily. DAC: 1-2x weekly

Delivery Methods

subcutaneous

👃 This peptide is also available in nasal spray form from select suppliers.

Available Forms

• Subcutaneous injection

⚠️ Not Medical Advice: Dosing information is compiled from published research and clinical studies for educational purposes only. This is not a recommendation. All peptide research should be conducted by qualified professionals in controlled research environments. Consult a healthcare provider before considering any protocol.

Cost Context

Research-grade CJC-1295 (no DAC): $30-60 per 2mg vial. DAC version: $40-80 per 2mg. Monthly costs: No DAC $60-150/month, DAC $40-80/month due to less frequent dosing.

Prices vary by region, source, and insurance coverage. This is general context only.

Where to Buy

Looking for quality CJC-1295? Check our vetted suppliers.

View Trusted Suppliers

Related Peptides

💪Ipamorelin

A cleaner growth hormone secretagogue with minimal side effects. Great for sleep, recovery, and body composition.

💪Sermorelin

The original GHRH analog. Stimulates natural GH production with a good safety profile. Popular for anti-aging.

Pairs Well With

💪Ipamorelin

Learn about stacking →

⚠️ Important Disclaimer

This information is for educational purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use by the FDA. Always consult with a qualified healthcare provider before starting any peptide protocol. PepGains does not sell peptides and is not responsible for how this information is used. All timeline and efficacy information is based on published research and clinical trials - individual results may vary significantly.