Quick Take
PT-141 is FDA-approved for female sexual dysfunction (as Vyleesi). Unlike Viagra which works on blood flow, PT-141 works in the brain to increase desire. It's the only FDA-approved drug that targets libido directly.
How It Works
Simple Explanation
PT-141 activates melanocortin receptors in the brain that control sexual arousal. It increases desire and arousal by working on the central nervous system, not blood flow.
🔬 Technical Details (Click to expand)
As a melanocortin-4 receptor (MC4R) agonist, bremelanotide activates pathways in the hypothalamus associated with sexual arousal. It's derived from melanotan-II but without significant tanning effects at therapeutic doses.
Key Research
RECONNECT Trials
Significant improvement in sexual desire and distress in women
Male Studies
Effective for erectile dysfunction in men, including those who don't respond to Viagra
Mechanism
First drug to work on central arousal pathways
Benefits
- Increases sexual desire centrally
- Works for people who don't respond to blood flow drugs
- FDA approved (as Vyleesi)
- Effects both men and women
- Works on arousal, not just mechanics
Side Effects
- Nausea — Very common (40%)Main limiting factor
- Flushing — Common
- Headache — Common
- Transient blood pressure increase — CommonMonitor if hypertensive
Typical Dosing
Standard Dose
1.75mg (FDA dose) or 0.5-2mg (research)
Forms Available
- • Subcutaneous injection
- • Nasal spray (research)
Frequency
As needed, at least 45 min before activity. Max 8 doses/month
⚠️ This is general information only. Always consult a healthcare provider before starting any peptide.
Who It's For
- ✓ Women with hypoactive sexual desire
- ✓ Men with ED not responding to PDE5 inhibitors
- ✓ Those seeking central arousal enhancement
Who Should Avoid
- ✗ Uncontrolled hypertension
- ✗ Cardiovascular disease
- ✗ Those who can't tolerate nausea
- ✗ Frequent use (max 8x/month)
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