Quick Take
MOTS-c is an 'exercise mimetic' — it activates the same pathways that exercise does (AMPK). Early research shows metabolic benefits, improved insulin sensitivity, and potential longevity effects. It's like your mitochondria's own fitness peptide.
How It Works
Simple Explanation
MOTS-c comes from your mitochondria and activates AMPK, the same enzyme that exercise turns on. This improves how your body uses energy, burns fat, and handles blood sugar.
🔬 Technical Details (Click to expand)
As a mitochondrial-derived peptide, MOTS-c activates AMPK via folate-methionine cycle regulation. It improves glucose uptake, increases fatty acid oxidation, and enhances mitochondrial function.
Key Research
Exercise Mimetic
Activates AMPK similar to exercise
Metabolic Benefits
Improved insulin sensitivity and glucose handling in mice
Longevity
Extended healthspan in animal models
Benefits
- Mimics metabolic benefits of exercise
- Improved insulin sensitivity
- Potential longevity benefits
- Mitochondrial support
- May help with metabolic syndrome
Side Effects
- Limited data — UnknownResearch is early-stage
Typical Dosing
Standard Dose
5-10mg daily or several times weekly
Forms Available
- • Subcutaneous injection
Frequency
Daily or 3-5x weekly
⚠️ This is general information only. Always consult a healthcare provider before starting any peptide.
Who It's For
- ✓ Metabolic optimization enthusiasts
- ✓ Those who can't exercise fully
- ✓ Longevity biohackers
- ✓ Researchers and early adopters
Who Should Avoid
- ✗ Those wanting proven compounds
- ✗ Risk-averse individuals
- ✗ Anyone expecting exercise replacement
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